Neuromuscular blocking agents (NMBs) are used to induce total paralysis to permit intubation and muscle relaxation during surgery or in ventilated patients. NMBs permit a very rapid induction of neuromuscular blockade at the onset of use, and the reversal agent will provide for more rapid reversal of the neuromuscular blockade. We are developing an intermediate-acting NMB, BX-1000, an ultrashort-acting NMB, BX-2000, and a reversal agent (BX-3000) specific to our NMBs. The table below summarizes the predicted onset and duration of action for each NMB based on currently available data, as well as the development status of each NMB:
|Compound||Onset Time||Duration of Action||Status|
In animal models, the proprietary reversal agent acts quickly by chemical reaction to reverse the neuromuscular blockade. We believe that the NMBs can reduce the time required for induction of anesthesia and the reversal agent can reduce the time needed to recover from NMB dosing post-procedure, while potentially enhancing patient safety and resulting in cost savings for the hospital or another provider.
More information on our neuromuscular blocking agents and reversal agent can be found in the following publications:
We have a worldwide, exclusive license to the NMBs and the related reversal agent from Cornell University.